Dear Colleague,

At OneOncology, our Clinical team’s work is guided by a clear and enduring principle: access matters.

Access to high-quality cancer care close to home. Access for physicians to leadership and business experience. Access to colleagues for decision-making support and shared expertise. And access to innovation that advances cancer care and improves outcomes for patients. Over the past year, these priorities have shaped our clinical investments and strategic path.

Our foremost focus remains expanding access to exceptional cancer care in the communities our practices serve. Community oncology is a model that — when guided by physician leadership that has the right infrastructure in place — delivers high-quality, patient-centered care where patients want to receive it: close to home, near their families and support networks. By strengthening clinical capabilities across our platform, we continue to ensure our partner practices can deliver complex, coordinated care to their patients.

Equally important is access for physicians. We believe the best decisions in medicine are made by the physicians who deliver care daily. We were founded on the idea that physicians are best equipped to be directly involved in decisions affecting both clinical care and operations, and we expanded on that premise in 2025. We enhanced our clinical leadership to reflect the full continuum of cancer care including medical oncology, radiation oncology, surgery, pharmacy, precision medicine, and clinical research. These investments reinforce our commitment to physician-led decision making and multidisciplinary collaboration.

OneOncology’s network of physician leaders from across the country continues to be a powerful catalyst for progress. Through OneCouncil and our Disease Groups, physicians across the network help define clinical priorities and identify opportunities to improve care. Rather than rebuilding processes practice by practice, in 2025 we focused on scaling proven models and enabling practices to learn from peers already delivering advanced services. When needed, we partner with best-in-class external organizations to ensure programs are implemented effectively and sustainably.

This collaborative approach has accelerated our ability to expand access to advanced therapies. Over the past year, we invested in the growth of cellular therapy, radioligand therapy, and T-cell engagers. Today, three OneOncology partner practices provide cellular therapy services, with plans to double or triple that number in 2026. Our goal is clear: deliver cutting-edge treatments safely and consistently, closer to patients’ homes, while maintaining the highest clinical standards. We also expanded partnerships supporting services such as Chronic Care Management, and plan to expand others, like Collaborative Care Models, further strengthening our physicians and care teams’ ability to deliver comprehensive, longitudinal care, seamlessly.

Quality measurement and reporting remain central to demonstrating the value of community oncology. In 2025, we enhanced our ability to report for government programs such as MIPS, securing CMS approval for meaningful quality measures that support our goals to improve access in a variety of ways. Looking ahead, we are prioritizing patient-centered measures, including time to a patient’s first oncology visit and responsiveness to patient-reported symptoms.

Finally, we continued to expand access to clinical research. By centralizing trial prescreening, accelerating activation, and providing consistent regulatory and operational support, we are making clinical trials feasible in community practices in both rural and urban settings, ensuring that research is reflective of U.S. patient populations. Research remains a vital pathway for bringing innovation directly to patients where they receive care, and we are proud to help our practice partners enroll patients in innovative clinical trials.

As we look forward, we remain committed to scaling clinical capabilities, strengthening physician leadership, mentoring the next generation of physician leaders, and expanding access to innovation, quality, and research — always with the goal of making cancer care better for our patients.

Sincerely,